Oxidative Damage to RNA is Altered by the Presence of Interacting Proteins or Modified Nucleosides

Oxidative Damage to RNA is Altered by the Presence of Interacting Proteins or Modified Nucleosides

Oxidative stress triggered by the Fenton reaction (chemical) or UVR exposure (photo) can damage cellular biomolecules including RNA through oxidation of nucleotides. Besides such xenobiotic chemical modifications, RNA also contains several post-transcriptional nucleoside modifications that are insta...

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Bibliographic Details
Main Authors: Mariana Estevez, Satenik Valesyan, Manasses Jora, Patrick A. Limbach, Balasubrahmanyam Addepalli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
oxidative stress
post-transcriptional modifications
RNA damage
8-oxo-G
ribosomes
mnm 5s2U
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.697149/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.697149/full

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