Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation

Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation

Knowledge on how antibody responses have evolved is critical for the induction of protective immunity. Here the authors analyse, using high-throughput sequencing of both exon and intron regions, the mutation and lineage development of an HIV-neutralizing antibody to find an unexpected early emergenc...

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Bibliographic Details
Main Authors: Erik L. Johnson, Nicole A. Doria-Rose, Jason Gorman, Jinal N. Bhiman, Chaim A. Schramm, Ashley Q. Vu, William H. Law, Baoshan Zhang, Valerie Bekker, Salim S. Abdool Karim, Gregory C. Ippolito, Lynn Morris, Penny L. Moore, Peter D. Kwong, John R. Mascola, George Georgiou
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06424-6

Internet

https://doi.org/10.1038/s41467-018-06424-6

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