Intronic <i>TP53</i> Polymorphisms Are Associated with Increased <i>Δ133TP53</i> Transcript, Immune Infiltration and Cancer Risk

Intronic <i>TP53</i> Polymorphisms Are Associated with Increased <i>Δ133TP53</i> Transcript, Immune Infiltration and Cancer Risk

We investigated the influence of selected <i>TP53</i> SNPs in exon 4 and intron 4 on cancer risk, clinicopathological features and expression of <i>TP53</i> isoforms. The intron 4 SNPs were significantly over-represented in cohorts of mixed cancers compared to three ethnicall...

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Bibliographic Details
Main Authors: Ramona A. Eiholzer, Sunali Mehta, Marina Kazantseva, Catherine J. Drummond, Cushla McKinney, Katie Young, David Slater, Brianna C. Morten, Kelly A. Avery-Kiejda, Annette Lasham, Nicholas Fleming, Helen R. Morrin, Karen Reader, Janice A. Royds, Michael Landmann, Simone Petrich, Roger Reddel, Lily Huschtscha, Ahmad Taha, Noelyn A. Hung, Tania L. Slatter, Antony W. Braithwaite
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
single nucleotide polymorphism
<i>TP53</i>
glioblastoma
prostate cancer
Δ133p53
rs1042522
Online Access:https://www.mdpi.com/2072-6694/12/9/2472

Internet

https://www.mdpi.com/2072-6694/12/9/2472

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