MEDALT: single-cell copy number lineage tracing enabling gene discovery

MEDALT: single-cell copy number lineage tracing enabling gene discovery

Abstract We present a Minimal Event Distance Aneuploidy Lineage Tree (MEDALT) algorithm that infers the evolution history of a cell population based on single-cell copy number (SCCN) profiles, and a statistical routine named lineage speciation analysis (LSA), whichty facilitates discovery of fitness...

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Bibliographic Details
Main Authors: Fang Wang, Qihan Wang, Vakul Mohanty, Shaoheng Liang, Jinzhuang Dou, Jincheng Han, Darlan Conterno Minussi, Ruli Gao, Li Ding, Nicholas Navin, Ken Chen
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Genome Biology
Subjects:
Single-cell
scDNA-seq
scRNA-seq
Copy number alteration
Tumor evolution
Lineage tracing
Online Access:https://doi.org/10.1186/s13059-021-02291-5

Internet

https://doi.org/10.1186/s13059-021-02291-5

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