Cardiac remodeling during and after renin–angiotensin system stimulation in Cyp1a1-Ren2 transgenic rats

Cardiac remodeling during and after renin–angiotensin system stimulation in Cyp1a1-Ren2 transgenic rats

This study investigated renin–angiotensin system (RAS)-induced cardiac remodeling and its reversibility in the presence and absence of high blood pressure (BP) in Cyp1a1-Ren2 transgenic inducible hypertensive rats (IHR). In IHR (pro)renin levels and BP can be dose-dependently titrated by oral admini...

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Bibliographic Details
Main Authors: Bart FJ Heijnen, Leonie PJ Pelkmans, AH Jan Danser, Ingrid M Garrelds, John J Mullins, Jo GR De Mey, Harry AJ Struijker-Boudier, Ben JA Janssen
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2014-03-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320313480537

Internet

https://doi.org/10.1177/1470320313480537

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