Smad3-mSin3A-HDAC1 Complex is Required for TGF-β1-Induced Transcriptional Inhibition of PPARγ in Mouse Cardiac Fibroblasts

Smad3-mSin3A-HDAC1 Complex is Required for TGF-β1-Induced Transcriptional Inhibition of PPARγ in Mouse Cardiac Fibroblasts

Background: We have recently demonstrated that activated transforming growth factor-β (TGF-β) signaling suppresses myocardial peroxisome proliferator-activated receptor γ (PPARγ) expression in the pressure overloaded heart. In this study, we aim to further define the molecular...

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Bibliographic Details
Main Authors: Kaizheng Gong, Mingxing Chen, Rujun Li, Yanghong He, Huajiang Zhu, Dan Yao, Suzanne Oparil, Zhengang Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
TGF-β
Cardiac fibrosis
PPARγ
Smad3
mSin3A
Online Access:http://www.karger.com/Article/FullText/453149

Internet

http://www.karger.com/Article/FullText/453149

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