Mechanical Postconditioning Promotes Glucose Metabolism and AMPK Activity in Parallel with Improved Post-Ischemic Recovery in an Isolated Rat Heart Model of Donation after Circulatory Death

Mechanical Postconditioning Promotes Glucose Metabolism and AMPK Activity in Parallel with Improved Post-Ischemic Recovery in an Isolated Rat Heart Model of Donation after Circulatory Death

Donation after circulatory death (DCD) could improve donor heart availability; however, warm ischemia-reperfusion injury raises concerns about graft quality. Mechanical postconditioning (MPC) may limit injury, but mechanisms remain incompletely characterized. Therefore, we investigated the roles of...

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Bibliographic Details
Main Authors: Maria Arnold, Natalia Méndez-Carmona, Patrik Gulac, Rahel K Wyss, Nina Rutishauser, Adrian Segiser, Thierry Carrel, Sarah Longnus
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
cardiac ischemia reperfusion injury
donation after circulatory death
postconditioning
contractile function
glucose metabolism
Online Access:https://www.mdpi.com/1422-0067/21/3/964

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https://www.mdpi.com/1422-0067/21/3/964

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