Catalyst-free assembly of giant tris(heteroaryl)methanes: synthesis of novel pharmacophoric triads and model sterically crowded tris(heteroaryl/aryl)methyl cation salts

Catalyst-free assembly of giant tris(heteroaryl)methanes: synthesis of novel pharmacophoric triads and model sterically crowded tris(heteroaryl/aryl)methyl cation salts

A series of giant tris(heteroaryl)methanes are easily assembled by one-pot three-component synthesis by simple reflux in ethanol without catalyst or additives. Diversely substituted indoles (Ar1) react with quinoline aldehydes, quinolone aldehydes, chromone aldehydes, and fluorene aldehydes (Ar2CHO)...

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Bibliographic Details
Main Authors: Rodrigo Abonia, Luisa F. Gutiérrez, Braulio Insuasty, Jairo Quiroga, Kenneth K. Laali, Chunqing Zhao, Gabriela L. Borosky, Samantha M. Horwitz, Scott D. Bunge
Format: Article
Language:English
Published: Beilstein-Institut 2019-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
model heteroarylmethylium salts
multicomponent
one-pot catalyst-free assembly
pharmacophoric triads
three-component synthesis
tris(heteroaryl)methanes
Yonemitsu-type reaction
Online Access:https://doi.org/10.3762/bjoc.15.60

Internet

https://doi.org/10.3762/bjoc.15.60

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