HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

HIV-1 must replicate in cells that are equipped to defend themselves from infection through intracellular innate immune systems. HIV-1 evades innate immune sensing through encapsidated DNA synthesis and encodes accessory genes that antagonize specific antiviral effectors. Here, we show that both par...

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Bibliographic Details
Main Authors: Hataf Khan, Rebecca P Sumner, Jane Rasaiyaah, Choon Ping Tan, Maria Teresa Rodriguez-Plata, Chris Van Tulleken, Douglas Fink, Lorena Zuliani-Alvarez, Lucy Thorne, David Stirling, Richard SB Milne, Greg J Towers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
HIV-1
Vpr
innate immunity
DNA sensing
IRF3
nf-kappa-b
Online Access:https://elifesciences.org/articles/60821

Internet

https://elifesciences.org/articles/60821

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