Intranasal Immunization with the Influenza A Virus Encoding Truncated NS1 Protein Protects Mice from Heterologous Challenge by Restraining the Inflammatory Response in the Lungs

Intranasal Immunization with the Influenza A Virus Encoding Truncated NS1 Protein Protects Mice from Heterologous Challenge by Restraining the Inflammatory Response in the Lungs

Influenza viruses with an impaired NS1 protein are unable to antagonize the innate immune system and, therefore, are highly immunogenic because of the self-adjuvating effect. Hence, NS1-mutated viruses are considered promising candidates for the development of live-attenuated influenza vaccines and...

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Bibliographic Details
Main Authors: Kirill Vasilyev, Anna-Polina Shurygina, Maria Sergeeva, Marina Stukova, Andrej Egorov
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Microorganisms
Subjects:
influenza virus
NS1 protein
immune response
immunogenicity
flow cytometry
Online Access:https://www.mdpi.com/2076-2607/9/4/690

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https://www.mdpi.com/2076-2607/9/4/690

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