A-769662 Protects Osteoblasts from Hydrogen Dioxide-Induced Apoptosis through Activating of AMP-Activated Protein Kinase (AMPK)

A-769662 Protects Osteoblasts from Hydrogen Dioxide-Induced Apoptosis through Activating of AMP-Activated Protein Kinase (AMPK)

Here we report that 5'-monophosphate (AMP)-activated protein kinase (AMPK) agonist A-769662 inhibited hydrogen peroxide (H2O2)-induced viability loss and apoptosis of human and mouse osteoblast cells. H2O2-induced moderate AMPK activation in osteoblast cells, which was enhanced by A-769662. Ina...

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Bibliographic Details
Main Authors: Yalong Zhu, Jianhua Zhou, Rongguang Ao, Baoqing Yu
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:International Journal of Molecular Sciences
Subjects:
osteonecrosis
AMPK
A-769662
oxidative stress and apoptosis
Online Access:http://www.mdpi.com/1422-0067/15/6/11190

Internet

http://www.mdpi.com/1422-0067/15/6/11190

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