Nicotinamide Treatment Facilitates Mitochondrial Fission through Drp1 Activation Mediated by SIRT1-Induced Changes in Cellular Levels of cAMP and Ca<sup>2+</sup>

Nicotinamide Treatment Facilitates Mitochondrial Fission through Drp1 Activation Mediated by SIRT1-Induced Changes in Cellular Levels of cAMP and Ca<sup>2+</sup>

Mitochondrial autophagy (or mitophagy) is essential for mitochondrial quality control, which is critical for cellular and organismal health by attenuating reactive oxygen species generation and maintaining bioenergy homeostasis. Previously, we showed that mitophagy is activated in human cells throug...

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Bibliographic Details
Main Authors: Seon Beom Song, Jin Sung Park, So Young Jang, Eun Seong Hwang
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
nicotinamide
mitochondrial fragmentation
SIRT1
AMPK
Drp1
calcineurin
Online Access:https://www.mdpi.com/2073-4409/10/3/612

Internet

https://www.mdpi.com/2073-4409/10/3/612

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