Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem Cells

Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem Cells

Extracellular vesicles (EVs), including exosomes and microvesicles, function in cell-to-cell communication through delivery of proteins, lipids and microRNAs to target cells via endocytosis and membrane fusion. These vesicles are enriched in ceramide, a sphingolipid associated with the promotion of...

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Bibliographic Details
Main Authors: Andrew Khayrullin, Priyanka Krishnan, Luis Martinez-Nater, Bharati Mendhe, Sadanand Fulzele, Yutao Liu, Julie A. Mattison, Mark W. Hamrick
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
aging
neutral sphingomyelinase 2
cell-cell communication
extracellular vesicles
Online Access:http://www.mdpi.com/2073-4409/8/1/37

Internet

http://www.mdpi.com/2073-4409/8/1/37

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