Tacrolimus Induces Insulin Resistance and Increases the Glucose Absorption in the Jejunum: A Potential Mechanism of the Diabetogenic Effects.

Tacrolimus Induces Insulin Resistance and Increases the Glucose Absorption in the Jejunum: A Potential Mechanism of the Diabetogenic Effects.

The use of the immunosuppressive drug tacrolimus (TAC) is related to new onset diabetes after transplantation. Herein, we examined the effect of intraperitoneal administered TAC on intestinal glucose absorption in mice.Animals received low, medium, or high dose TAC (0.5, 1, or 5 mg/kg/d, respectivel...

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Bibliographic Details
Main Authors: Zhiwei Li, Fei Sun, Yaohui Zhang, Hao Chen, Ningning He, Hui Chen, Penghong Song, Yan Wang, Sheng Yan, Shusen Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4657894?pdf=render

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http://europepmc.org/articles/PMC4657894?pdf=render

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