Disrupting the Btk Pathway Suppresses COPD-Like Lung Alterations in Atherosclerosis Prone ApoE−/− Mice Following Regular Exposure to Cigarette Smoke

Disrupting the Btk Pathway Suppresses COPD-Like Lung Alterations in Atherosclerosis Prone ApoE−/− Mice Following Regular Exposure to Cigarette Smoke

Chronic obstructive pulmonary disease (COPD) is associated with severe chronic inflammation that promotes irreversible tissue destruction. Moreover, the most broadly accepted cause of COPD is exposure to cigarette smoke. There is no effective cure and significantly, the mechanism behind the developm...

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Bibliographic Details
Main Authors: Jon M. Florence, Agnieszka Krupa, Laela M. Booshehri, Adrian L. Gajewski, Anna K. Kurdowska
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:International Journal of Molecular Sciences
Subjects:
chronic lung inflammation
emphysema
second hand smoke
Bruton’s tyrosine kinase
matrix metalloproteinase-9
Online Access:http://www.mdpi.com/1422-0067/19/2/343

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http://www.mdpi.com/1422-0067/19/2/343

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