Bone marrow derived mesenchymal stem cells ameliorate inflammatory response in an in vitro model of familial hemophagocytic lymphohistiocytosis 2

Bone marrow derived mesenchymal stem cells ameliorate inflammatory response in an in vitro model of familial hemophagocytic lymphohistiocytosis 2

Abstract Background Familial hemophagocytic lymphohistiocytosis 2 (FHL2) is the most common familial type of hemophagocytic lymphohistiocytosis with immune dysregulation. FHL2 patients have mutations in the perforin gene which cause overactivation and proliferation of cytotoxic T lymphocytes and nat...

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Bibliographic Details
Main Authors: Handan Sevim, Yusuf Çetin Kocaefe, Mehmet Ali Onur, Duygu Uçkan-Çetinkaya, Özer Aylin Gürpınar
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Stem Cell Research & Therapy
Subjects:
Familial hemophagocytic lymphohistiocytosis 2
Perforin
Mesenchymal stem cells
CRISPR/Cas
Immune modulation
Online Access:http://link.springer.com/article/10.1186/s13287-018-0941-y

Internet

http://link.springer.com/article/10.1186/s13287-018-0941-y

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