Structural integrity of the antigen is a determinant for the induction of T-helper type-1 immunity in mice by gene gun vaccines against E. coli beta-galactosidase.

Structural integrity of the antigen is a determinant for the induction of T-helper type-1 immunity in mice by gene gun vaccines against E. coli beta-galactosidase.

The type of immune response is critical for successful protection and typically determined by pathogen-associated danger molecules. In contrast, protein antigens are usually regarded as passive target structures. Here, we provide evidence that the structure of the antigen can profoundly influence th...

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Bibliographic Details
Main Authors: Tekalign Deressa, Angelika Stoecklinger, Michael Wallner, Martin Himly, Stefan Kofler, Katrina Hainz, Hans Brandstetter, Josef Thalhamer, Peter Hammerl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4099185?pdf=render

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http://europepmc.org/articles/PMC4099185?pdf=render

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