Effects of Differences in Lipid A Structure on TLR4 Pro-inflammatory Signaling and Inflammasome Activation

The vertebrate immune system exists in equilibrium with the microbial world. The innate immune system recognizes pathogen-associated molecular patterns via a family of Toll-like receptors that activate cells upon detection of potential pathogens. Because some microbes benefit their hosts, mobilizi...

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Bibliographic Details
Main Authors: Paula M Chilton, Chelsea A Embry, Thomas C Mitchell
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Immunology
Subjects:
LPS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00154/full