Identification and Characterization of CD44RC, a Novel Alternatively Spliced Soluble CD44 Isoform that can Potentiate the Hyaluronan Binding Activity of Cell Surface CD44

Identification and Characterization of CD44RC, a Novel Alternatively Spliced Soluble CD44 Isoform that can Potentiate the Hyaluronan Binding Activity of Cell Surface CD44

Soluble CD44 proteins generated by proteolytic cleavage or aberrant intron retention have been shown to antagonize the ligand binding activity of the corresponding cell surface receptor, inducing apoptosis and inhibiting tumor growth. Interestingly, such findings appear to contradict recent studies...

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Bibliographic Details
Main Authors: Roland K. Chiu, Carmine Carpenito, Shona T. Dougherty, Gregory M. Hayes, Graeme J. Dougherty
Format: Article
Language:English
Published: Elsevier 1999-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
CD44
hyaluronan
chondroitin sulfate
alternative splicing
leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558699800165

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http://www.sciencedirect.com/science/article/pii/S1476558699800165

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