Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Activity Towards Antibiotic Resistance of MBIs

Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Activity Towards Antibiotic Resistance of MBIs

The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis calls for an immediate search for novel treatment strategies. Recently, BlaC, the principal beta-lactamase of Mycobacterium tuberculosis, was recognized as a potential therapeutic target. BlaC belongs to Amb...

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Bibliographic Details
Main Authors: Sourya Bhattacharya, Vivek Junghare, Niteesh Kumar Pandey, Subhecchha Baidya, Harsha Agarwal, Neeladrisingha Das, Ayan Banerjee, Debashish Ghosh, Partha Roy, Hirak K. Patra, Saugata Hazra
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Microbiology
Subjects:
antimicrobial resistance (AMR)
multidrug-resistant (MDR)
extensively drug-resistant (XDR)
Mycobacterium tuberculosis
conserved loop
MD simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.710291/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.710291/full

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