Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11 [version 1; peer review: 1 approved, 2 approved with reservations]
Background: Bile salt export pump (BSEP/ABCB11) is important in the maintenance of the enterohepatic circulation of bile acids and drugs. Drugs such as rifampicin and glibenclamide inhibit BSEP. Progressive familial intrahepatic cholestasis type-2, a lethal pediatric disease, some forms of intrahepa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2020-12-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/9-1497/v1 |