Transancestral mapping and genetic load in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hypothesis for loci conferring risk to SLE.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms16021 |
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Carl D. Langefeld Hannah C. Ainsworth Deborah S. Cunninghame Graham Jennifer A. Kelly Mary E. Comeau Miranda C. Marion Timothy D. Howard Paula S. Ramos Jennifer A. Croker David L. Morris Johanna K. Sandling Jonas Carlsson Almlöf Eduardo M. Acevedo-Vásquez Graciela S. Alarcón Alejandra M. Babini Vicente Baca Anders A. Bengtsson Guillermo A. Berbotto Marc Bijl Elizabeth E. Brown Hermine I. Brunner Mario H. Cardiel Luis Catoggio Ricard Cervera Jorge M. Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D’Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C. Edberg Emőke Endreffy Jorge A. Esquivel-Valerio Paul R. Fortin Barry I. Freedman Johan Frostegård Mercedes A. García Ignacio García de la Torre Gary S. Gilkeson Dafna D. Gladman Iva Gunnarsson Joel M. Guthridge Jennifer L. Huggins Judith A. James Cees G. M. Kallenberg Diane L. Kamen David R. Karp Kenneth M. Kaufman Leah C. Kottyan László Kovács Helle Laustrup Bernard R. Lauwerys Quan-Zhen Li Marco A. Maradiaga-Ceceña Javier Martín Joseph M. McCune David R. McWilliams Joan T. Merrill Pedro Miranda José F. Moctezuma Swapan K. Nath Timothy B. Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A. Pineau Bernardo A. Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D. Reveille Laurie P. Russell José M. Sabio Carlos A. Aguilar-Salinas Hugo R. Scherbarth Raffaella Scorza Michael F. Seldin Christopher Sjöwall Elisabet Svenungsson Susan D. Thompson Sergio M. A. Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M. Vilá Daniel J. Wallace Michael H. Weisman Joan E. Wither Tushar Bhangale Jorge R. Oksenberg John D. Rioux Peter K. Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A. Criswell Chaim O. Jacob Kathy L. Sivils Betty P. Tsao Laura E. Schanberg Timothy W. Behrens Earl D. Silverman Marta E. Alarcón-Riquelme Robert P. Kimberly John B. Harley Edward K. Wakeland Robert R. Graham Patrick M. Gaffney Timothy J. Vyse |
| spellingShingle |
Carl D. Langefeld Hannah C. Ainsworth Deborah S. Cunninghame Graham Jennifer A. Kelly Mary E. Comeau Miranda C. Marion Timothy D. Howard Paula S. Ramos Jennifer A. Croker David L. Morris Johanna K. Sandling Jonas Carlsson Almlöf Eduardo M. Acevedo-Vásquez Graciela S. Alarcón Alejandra M. Babini Vicente Baca Anders A. Bengtsson Guillermo A. Berbotto Marc Bijl Elizabeth E. Brown Hermine I. Brunner Mario H. Cardiel Luis Catoggio Ricard Cervera Jorge M. Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D’Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C. Edberg Emőke Endreffy Jorge A. Esquivel-Valerio Paul R. Fortin Barry I. Freedman Johan Frostegård Mercedes A. García Ignacio García de la Torre Gary S. Gilkeson Dafna D. Gladman Iva Gunnarsson Joel M. Guthridge Jennifer L. Huggins Judith A. James Cees G. M. Kallenberg Diane L. Kamen David R. Karp Kenneth M. Kaufman Leah C. Kottyan László Kovács Helle Laustrup Bernard R. Lauwerys Quan-Zhen Li Marco A. Maradiaga-Ceceña Javier Martín Joseph M. McCune David R. McWilliams Joan T. Merrill Pedro Miranda José F. Moctezuma Swapan K. Nath Timothy B. Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A. Pineau Bernardo A. Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D. Reveille Laurie P. Russell José M. Sabio Carlos A. Aguilar-Salinas Hugo R. Scherbarth Raffaella Scorza Michael F. Seldin Christopher Sjöwall Elisabet Svenungsson Susan D. Thompson Sergio M. A. Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M. Vilá Daniel J. Wallace Michael H. Weisman Joan E. Wither Tushar Bhangale Jorge R. Oksenberg John D. Rioux Peter K. Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A. Criswell Chaim O. Jacob Kathy L. Sivils Betty P. Tsao Laura E. Schanberg Timothy W. Behrens Earl D. Silverman Marta E. Alarcón-Riquelme Robert P. Kimberly John B. Harley Edward K. Wakeland Robert R. Graham Patrick M. Gaffney Timothy J. Vyse Transancestral mapping and genetic load in systemic lupus erythematosus Nature Communications |
| author_facet |
Carl D. Langefeld Hannah C. Ainsworth Deborah S. Cunninghame Graham Jennifer A. Kelly Mary E. Comeau Miranda C. Marion Timothy D. Howard Paula S. Ramos Jennifer A. Croker David L. Morris Johanna K. Sandling Jonas Carlsson Almlöf Eduardo M. Acevedo-Vásquez Graciela S. Alarcón Alejandra M. Babini Vicente Baca Anders A. Bengtsson Guillermo A. Berbotto Marc Bijl Elizabeth E. Brown Hermine I. Brunner Mario H. Cardiel Luis Catoggio Ricard Cervera Jorge M. Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D’Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C. Edberg Emőke Endreffy Jorge A. Esquivel-Valerio Paul R. Fortin Barry I. Freedman Johan Frostegård Mercedes A. García Ignacio García de la Torre Gary S. Gilkeson Dafna D. Gladman Iva Gunnarsson Joel M. Guthridge Jennifer L. Huggins Judith A. James Cees G. M. Kallenberg Diane L. Kamen David R. Karp Kenneth M. Kaufman Leah C. Kottyan László Kovács Helle Laustrup Bernard R. Lauwerys Quan-Zhen Li Marco A. Maradiaga-Ceceña Javier Martín Joseph M. McCune David R. McWilliams Joan T. Merrill Pedro Miranda José F. Moctezuma Swapan K. Nath Timothy B. Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A. Pineau Bernardo A. Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D. Reveille Laurie P. Russell José M. Sabio Carlos A. Aguilar-Salinas Hugo R. Scherbarth Raffaella Scorza Michael F. Seldin Christopher Sjöwall Elisabet Svenungsson Susan D. Thompson Sergio M. A. Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M. Vilá Daniel J. Wallace Michael H. Weisman Joan E. Wither Tushar Bhangale Jorge R. Oksenberg John D. Rioux Peter K. Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A. Criswell Chaim O. Jacob Kathy L. Sivils Betty P. Tsao Laura E. Schanberg Timothy W. Behrens Earl D. Silverman Marta E. Alarcón-Riquelme Robert P. Kimberly John B. Harley Edward K. Wakeland Robert R. Graham Patrick M. Gaffney Timothy J. Vyse |
| author_sort |
Carl D. Langefeld |
| title |
Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_short |
Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_full |
Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_fullStr |
Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_full_unstemmed |
Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_sort |
transancestral mapping and genetic load in systemic lupus erythematosus |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-07-01 |
| description |
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hypothesis for loci conferring risk to SLE. |
| url |
https://doi.org/10.1038/ncomms16021 |
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1721452948291059712 |
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doaj-a68227bc3ba0457486591e4743061bf92021-05-11T07:03:41ZengNature Publishing GroupNature Communications2041-17232017-07-018111810.1038/ncomms16021Transancestral mapping and genetic load in systemic lupus erythematosusCarl D. Langefeld0Hannah C. Ainsworth1Deborah S. Cunninghame Graham2Jennifer A. Kelly3Mary E. Comeau4Miranda C. Marion5Timothy D. Howard6Paula S. Ramos7Jennifer A. Croker8David L. Morris9Johanna K. Sandling10Jonas Carlsson Almlöf11Eduardo M. Acevedo-Vásquez12Graciela S. Alarcón13Alejandra M. Babini14Vicente Baca15Anders A. Bengtsson16Guillermo A. Berbotto17Marc Bijl18Elizabeth E. Brown19Hermine I. Brunner20Mario H. Cardiel21Luis Catoggio22Ricard Cervera23Jorge M. Cucho-Venegas24Solbritt Rantapää Dahlqvist25Sandra D’Alfonso26Berta Martins Da Silva27Iñigo de la Rúa Figueroa28Andrea Doria29Jeffrey C. Edberg30Emőke Endreffy31Jorge A. Esquivel-Valerio32Paul R. Fortin33Barry I. Freedman34Johan Frostegård35Mercedes A. García36Ignacio García de la Torre37Gary S. Gilkeson38Dafna D. Gladman39Iva Gunnarsson40Joel M. Guthridge41Jennifer L. Huggins42Judith A. James43Cees G. M. Kallenberg44Diane L. Kamen45David R. Karp46Kenneth M. Kaufman47Leah C. Kottyan48László Kovács49Helle Laustrup50Bernard R. Lauwerys51Quan-Zhen Li52Marco A. Maradiaga-Ceceña53Javier Martín54Joseph M. McCune55David R. McWilliams56Joan T. Merrill57Pedro Miranda58José F. Moctezuma59Swapan K. Nath60Timothy B. Niewold61Lorena Orozco62Norberto Ortego-Centeno63Michelle Petri64Christian A. Pineau65Bernardo A. Pons-Estel66Janet Pope67Prithvi Raj68Rosalind Ramsey-Goldman69John D. Reveille70Laurie P. Russell71José M. Sabio72Carlos A. Aguilar-Salinas73Hugo R. Scherbarth74Raffaella Scorza75Michael F. Seldin76Christopher Sjöwall77Elisabet Svenungsson78Susan D. Thompson79Sergio M. A. Toloza80Lennart Truedsson81Teresa Tusié-Luna82Carlos Vasconcelos83Luis M. Vilá84Daniel J. Wallace85Michael H. Weisman86Joan E. Wither87Tushar Bhangale88Jorge R. Oksenberg89John D. Rioux90Peter K. Gregersen91Ann-Christine Syvänen92Lars Rönnblom93Lindsey A. Criswell94Chaim O. Jacob95Kathy L. Sivils96Betty P. Tsao97Laura E. Schanberg98Timothy W. Behrens99Earl D. Silverman100Marta E. Alarcón-Riquelme101Robert P. Kimberly102John B. Harley103Edward K. Wakeland104Robert R. Graham105Patrick M. Gaffney106Timothy J. Vyse107Center for Public Health Genomics, Wake Forest School of MedicineCenter for Public Health Genomics, Wake Forest School of MedicineDivisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King’s College London, Guy’s HospitalArthritis & Clinical Immunology Research Program, Oklahoma Medical Research FoundationCenter for Public Health Genomics, Wake Forest School of MedicineCenter for Public Health Genomics, Wake Forest School of MedicineCenter for Public Health Genomics, Wake Forest School of MedicineDepartment of Public Health Sciences, Medical University of South CarolinaDivision of Clinical Immunology and Rheumatology, UAB School of MedicineDivisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King’s College London, Guy’s HospitalDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala UniversityDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala UniversityDepartamento de Reumatología, Hospital G. Almenara y Facultad de Medicina, Universidad Nacional Mayor de San MarcosDivision of Clinical Immunology and Rheumatology, UAB School of MedicineHospital Italiano de CórdobaHospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro SocialDepartment of Clinical Sciences, Rheumatology, Lund UniversityHospital Eva PerónDepartment of Internal Medicine and Rheumatology, Martini HospitalDivision of Clinical Immunology and Rheumatology, UAB School of MedicineDivision of Rheumatology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and the University of CincinnatiCentro de Investigación Clínica de MoreliaHospital Italiano de Buenos AiresDepartment of Autoimmune Diseases, Hospital Clínic, University of BarcelonaDepartamento de Reumatología, Hospital G. Almenara y Facultad de Medicina, Universidad Nacional Mayor de San MarcosDepartment of Public Health and Clinical Medicine, Division of Rheumatology, Umeå UniversityDepartment of Health Sciences and Institute of Research in Autoimmune Diseases (IRCAD), University of Eastern PiedmontUnidade Multidisciplinar em Investigação Biomédica/Instituto de Ciências Biomédicas de Abel Salazar—Universidade do PortoDepartment of Rheumatology, Hospital Universitario de Gran Canaria Dr NegrínDivision of Rheumatology, Department of Medicine (DIMED), University of PaduaDivision of Clinical Immunology and Rheumatology, UAB School of MedicineDepartment of Pediatrics and Child Health Center, Albert Szent-Györgyi Medical Center, Faculty of Medicine, University of SzegedHospital Universitario ‘Dr José Eleuterio González’ Universidad Autonoma de Nuevo LeónCHU de Québec Université LavalCenter for Public Health Genomics, Wake Forest School of MedicineInstitute of Environmental Medicine, Unit of Immunology and Chronic diseases, Karolinska InstitutetDivision of Rheumatology, Hospital Interzonal General de Agudos General San MartínDepartamento de Fisiología, University of GuadalajaraDepartment of Medicine, Medical University of South CarolinaCentre for Prognosis Studies in The Rheumatic Diseases, Krembil Research Institute, Toronto Western HospitalDepartment of Medicine Solna, Unit of Rheumatology, Karolinska Institutet, Karolinska University HospitalArthritis & Clinical Immunology Research Program, Oklahoma Medical Research FoundationDivision of Rheumatology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and the University of CincinnatiArthritis & Clinical Immunology Research Program, Oklahoma Medical Research FoundationDepartment of Rheumatology and Clinical Immunology,University Medical Center Groningen,University of GroningenDepartment of Medicine, Medical University of South CarolinaDepartment of Immunology, University of Texas SouthWestern Medical CenterDepartment of Pediatrics, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical CenterDepartment of Rheumatology, Albert Szent-Györgyi Medical Centre, University of SzegedDepartment of Rheumatology, Odense University HospitalRheumatology, Cliniques Universitaires Saint-Luc & Institut de Recherche Expérimentale et Clinique, Université catholique de LouvainDepartment of Immunology, University of Texas SouthWestern Medical CenterHospital General de CuliacánInstituto de Parasitología y Biomedicina López Neyra, CSICUniversity of Michigan Medical CenterCenter for Public Health Genomics, Wake Forest School of MedicineArthritis & Clinical Immunology Research Program, Oklahoma Medical Research FoundationCentro de Estudios Reumatológicos, Santiago de ChileDepartamento de Reumatología, Hospital General de MéxicoArthritis & Clinical Immunology Research Program, Oklahoma Medical Research FoundationDepartment of Rheumatology, Mayo ClinicInstituto Nacional de Medicina Genómica (INMEGEN)Unidad de Enfermedades Autoimmunes Sistémicas, UGC Medicina Interna, Hospital Universitario San CecilioDivision of Rheumatology, Department of Medicine, Johns Hopkins University School of MedicineRheumatology Division, McGill UniversityDepartment of Rheumatology, Sanatorio ParqueUniversity of Western OntarioDepartment of Immunology, University of Texas SouthWestern Medical CenterDivision of Rheumatology, Northwestern University Feinberg School of MedicineThe University of Texas Health Science Center at Houston (UTHealth) Medical SchoolCenter for Public Health Genomics, Wake Forest School of MedicineHospital Universitario Virgen de las NievesDepartment of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y NutriciónUnidad Reumatología y Enfermedades Autoinmunes H.I.G.A. Dr Alende Mar del PlataReferral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca'Granda Ospedale Ma Repiore Policlinico and University of MilanDepartment of Biochemistry and Molecular Medicine, UC Davis School of MedicineRheumatology Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping UniversityDepartment of Medicine Solna, Unit of Rheumatology, Karolinska Institutet, Karolinska University HospitalDepartment of Pediatrics, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical CenterMinistry of Health, San Fernando del Valle de CatamarcaDepartment of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund UniversityUnidad de Biología Molecular y Medicina Genómica Instituto de Investigaciones Biomédicas/UNAM Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránHospital Santo Antonio, Universidade do PortoUniversity of Puerto Rico School of MedicineDepartment of Medicine, Cedars Sinai Medical CenterDepartment of Medicine, Cedars Sinai Medical CenterCentre for Prognosis Studies in The Rheumatic Diseases, Krembil Research Institute, Toronto Western HospitalHuman Genetics, Genentech Inc, South San FranciscoDepartment of Neurology and Institute of Human Genetics, University of California at San FranciscoUniversité de Montréal and the Montreal Heart InstituteCenter for Genomics & Human Genetics, The Feinstein Institute for Medical ResearchDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala UniversityDepartment of Medical Sciences, Rheumatology, Uppsala UniversityDivision of Rheumatology, Rosalind Russell/Ephraim P Engleman Rheumatology Research Center, UCSF School of MedicineKeck School of Medicine of USCArthritis & Clinical Immunology Research Program, Oklahoma Medical Research FoundationDepartment of Medicine, Medical University of South CarolinaDepartment of Pediatrics, Duke UniversityHuman Genetics, Genentech Inc, South San FranciscoDepartment of Pediatrics and the Institute of Medical Sciences, The Hospital for Sick Children, Hospital for Sick Children Research Institute and University of TorontoArthritis & Clinical Immunology Research Program, Oklahoma Medical Research FoundationDivision of Clinical Immunology and Rheumatology, UAB School of MedicineDepartment of Pediatrics, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical CenterDepartment of Immunology, University of Texas SouthWestern Medical CenterHuman Genetics, Genentech Inc, South San FranciscoArthritis & Clinical Immunology Research Program, Oklahoma Medical Research FoundationDivisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King’s College London, Guy’s HospitalSystemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hypothesis for loci conferring risk to SLE.https://doi.org/10.1038/ncomms16021 |