Differential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD.

The canonical Wnt/beta-catenin (Wnt) pathway is a master transcriptional regulatory signaling pathway that controls numerous biological processes including proliferation and differentiation. As such, transcriptional activity of the Wnt pathway is tightly regulated and/or modulated by numerous protei...

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Bibliographic Details
Main Authors: Brandon Beagle, Gail V W Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2911377?pdf=render