Pathogenic Germline Mutations of DNA Repair Pathway Components in Early-Onset Sporadic Colorectal Polyp and Cancer Patients

Pathogenic Germline Mutations of DNA Repair Pathway Components in Early-Onset Sporadic Colorectal Polyp and Cancer Patients

Given recent increases in the proportion of early-onset colorectal cancer (CRC), researchers are urgently working to establish a multi-gene screening test for both inherited and sporadic cancer-susceptible individuals. However, the incidence and spectrum of germline mutations in young sporadic CRC p...

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Bibliographic Details
Main Authors: Pi-Yueh Chang, Shih-Cheng Chang, Mei-Chia Wang, Jinn-Shiun Chen, Wen-Sy Tsai, Jeng-Fu You, Chia-Chun Chen, Hsiu-Ling Liu, Jy-Ming Chiang
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
early onset
colorectal cancer
cancer susceptibility gene
germline mutation
polyp
normal control
Online Access:https://www.mdpi.com/2072-6694/12/12/3560

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https://www.mdpi.com/2072-6694/12/12/3560

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