Blood Vessel Patterning on Retinal Astrocytes Requires Endothelial Flt-1 (VEGFR-1)

Feedback mechanisms are critical components of many pro-angiogenic signaling pathways that keep vessel growth within a functional range. The Vascular Endothelial Growth Factor-A (VEGF-A) pathway utilizes the decoy VEGF-A receptor Flt-1 to provide negative feedback regulation of VEGF-A signaling. In...

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Bibliographic Details
Main Authors: John C. Chappell, Jordan Darden, Laura Beth Payne, Kathryn Fink, Victoria L. Bautch
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Journal of Developmental Biology
Subjects:
Online Access:https://www.mdpi.com/2221-3759/7/3/18