Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

APC/C-mediated proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-counteracting phosphatases PP1 and PP2A-B55, allowing wide-spread dephosphorylation of substra...

Full description

Bibliographic Details
Main Authors: James Holder, Shabaz Mohammed, Francis A Barr
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
dephosphorylation
proteolysis
APC/C
PP1
mitotic exit
cell cycle
Online Access:https://elifesciences.org/articles/59885

Internet

https://elifesciences.org/articles/59885

Similar Items