Sonic hedgehog-Gli1 signaling pathway regulates the epithelial mesenchymal transition (EMT) by mediating a new target gene, S100A4, in pancreatic cancer cells.

Sonic hedgehog-Gli1 signaling pathway regulates the epithelial mesenchymal transition (EMT) by mediating a new target gene, S100A4, in pancreatic cancer cells.

The hedgehog signaling pathway plays an important role in EMT of pancreatic cancer cells, but the precise mechanisms remain elusive. Because S100A4 as a key EMT moleculer marker was found to be upregulated upon Gli1 in pancreatic cancer cells, we focused on the relationship between Shh-Gli1 signals...

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Bibliographic Details
Main Authors: Xuanfu Xu, Bin Su, Chuangao Xie, Shumei Wei, Yingqun Zhou, Hua Liu, Weiqi Dai, Ping Cheng, Fan Wang, Xiaorong Xu, Chuanyong Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4114558?pdf=render

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http://europepmc.org/articles/PMC4114558?pdf=render

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