Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

Abstract Background The extent to which changes in gene expression can influence cardiovascular disease risk across different tissue types has not yet been systematically explored. We have developed an analysis pipeline that integrates tissue-specific gene expression, Mendelian randomization and mul...

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Bibliographic Details
Main Authors: Kurt Taylor, George Davey Smith, Caroline L. Relton, Tom R. Gaunt, Tom G. Richardson
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Genome Medicine
Subjects:
Gene expression
DNA methylation
Tissue specificity
Cardiovascular disease
Mendelian randomization
Quantitative trait loci
Online Access:http://link.springer.com/article/10.1186/s13073-019-0613-2

Internet

http://link.springer.com/article/10.1186/s13073-019-0613-2

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