A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum.

A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum.

Resistance to the cytostatic activity of the antimalarial drug chloroquine (CQ) is becoming well understood, however, resistance to cytocidal effects of CQ is largely unexplored. We find that PfCRT mutations that almost fully recapitulate P. falciparum cytostatic CQ resistance (CQR(CS)) as quantifie...

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Bibliographic Details
Main Authors: David Gaviria, Michelle F Paguio, Lindsey B Turnbull, Asako Tan, Amila Siriwardana, Debasish Ghosh, Michael T Ferdig, Anthony P Sinai, Paul D Roepe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3835802?pdf=render

Internet

http://europepmc.org/articles/PMC3835802?pdf=render

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