Proteomics reveals novel oxidative and glycolytic mechanisms in type 1 diabetic patients' skin which are normalized by kidney-pancreas transplantation.

In type 1 diabetes (T1D) vascular complications such as accelerated atherosclerosis and diffused macro-/microangiopathy are linked to chronic hyperglycemia with a mechanism that is not yet well understood. End-stage renal disease (ESRD) worsens most diabetic complications, particularly, the risk of...

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Main Authors: Franco Folli, Valeria Guzzi, Lucia Perego, Dawn K Coletta, Giovanna Finzi, Claudia Placidi, Stefano La Rosa, Carlo Capella, Carlo Socci, Davide Lauro, Devjit Tripathy, Christopher Jenkinson, Rita Paroni, Elena Orsenigo, Giuliana Cighetti, Luisa Gregorini, Carlo Staudacher, Antonio Secchi, Angela Bachi, Michael Brownlee, Paolo Fiorina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2848014?pdf=render