Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice

Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice

Summary: We leverage the SM/J mouse to understand glycemic control in obesity. High-fat-fed SM/J mice initially develop poor glucose homeostasis relative to controls. Strikingly, their glycemic dysfunction resolves by 30 weeks of age despite persistent obesity. The mice dramatically expand their bro...

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Bibliographic Details
Main Authors: Caryn Carson, Juan F. Macias-Velasco, Subhadra Gunawardana, Mario A. Miranda, Sakura Oyama, Celine L. St. Pierre, Heather Schmidt, Jessica P. Wayhart, Heather A. Lawson
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
glycemic control
brown adipose
obesity
metabolism
mouse model
transcriptome
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312262

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http://www.sciencedirect.com/science/article/pii/S2211124720312262

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