Sorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in rats
A study on the effects of extruded sorghum bran (ESB) or raw sorghum bran (RSB) on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Four groups of male Wistar rats (six per group) consumed a basal die...
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doaj-a6b31955054c4fa888de3f2e50adf79d2020-12-17T14:55:54ZengTaylor & Francis GroupCyTA - Journal of Food1947-63371947-63452020-01-01181203010.1080/19476337.2019.17021051702105Sorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in ratsNorma Julieta Salazar-López0Gustavo A. González-Aguilar1Ofelia Rouzaud-Sández2Guadalupe Loarca-Piña3Shela Gorinstein4Maribel Robles-Sánchez5Universidad de SonoraCentro de Investigación en Alimentación y DesarrolloUniversidad de SonoraUniversidad Autónoma de QuerétaroThe Hebrew University -Hadassah Medical SchoolUniversidad de SonoraA study on the effects of extruded sorghum bran (ESB) or raw sorghum bran (RSB) on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Four groups of male Wistar rats (six per group) consumed a basal diet (BD), which were supplemented with either lard at 310 g/kg (HFD) or lard and ESB at 180 g/kg (HFD + ESB) or lard and RSB (HFD + RSB), for 8 weeks. The intake of HFD supplemented with ESB or RSB hindered the fat storage in adipocytes of abdominal tissue, dyslipidemia and the loss of glucose homeostasis. A positive correlation between inflammation biomarkers (Interleukin-1β and Interleukin-6) and glucose homeostasis was observed, while a negative correlation between antioxidant capacity (TEAC) and Interleukin-1β and Interleukin-6 was observed. As a conclusion, the ESB or RSB may be intended as part of healthy diets.http://dx.doi.org/10.1080/19476337.2019.1702105sorghum branhigh-fat dietinflammationdyslipidemia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Norma Julieta Salazar-López Gustavo A. González-Aguilar Ofelia Rouzaud-Sández Guadalupe Loarca-Piña Shela Gorinstein Maribel Robles-Sánchez |
spellingShingle |
Norma Julieta Salazar-López Gustavo A. González-Aguilar Ofelia Rouzaud-Sández Guadalupe Loarca-Piña Shela Gorinstein Maribel Robles-Sánchez Sorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in rats CyTA - Journal of Food sorghum bran high-fat diet inflammation dyslipidemia |
author_facet |
Norma Julieta Salazar-López Gustavo A. González-Aguilar Ofelia Rouzaud-Sández Guadalupe Loarca-Piña Shela Gorinstein Maribel Robles-Sánchez |
author_sort |
Norma Julieta Salazar-López |
title |
Sorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in rats |
title_short |
Sorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in rats |
title_full |
Sorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in rats |
title_fullStr |
Sorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in rats |
title_full_unstemmed |
Sorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in rats |
title_sort |
sorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in rats |
publisher |
Taylor & Francis Group |
series |
CyTA - Journal of Food |
issn |
1947-6337 1947-6345 |
publishDate |
2020-01-01 |
description |
A study on the effects of extruded sorghum bran (ESB) or raw sorghum bran (RSB) on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Four groups of male Wistar rats (six per group) consumed a basal diet (BD), which were supplemented with either lard at 310 g/kg (HFD) or lard and ESB at 180 g/kg (HFD + ESB) or lard and RSB (HFD + RSB), for 8 weeks. The intake of HFD supplemented with ESB or RSB hindered the fat storage in adipocytes of abdominal tissue, dyslipidemia and the loss of glucose homeostasis. A positive correlation between inflammation biomarkers (Interleukin-1β and Interleukin-6) and glucose homeostasis was observed, while a negative correlation between antioxidant capacity (TEAC) and Interleukin-1β and Interleukin-6 was observed. As a conclusion, the ESB or RSB may be intended as part of healthy diets. |
topic |
sorghum bran high-fat diet inflammation dyslipidemia |
url |
http://dx.doi.org/10.1080/19476337.2019.1702105 |
work_keys_str_mv |
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