Administration of a probiotic can change drug pharmacokinetics: effect of E. coli Nissle 1917 on amidarone absorption in rats.

The growing interest in the composition and effects of microbiota raised the question how drug pharmacokinetics could be influenced by concomitant application of probiotics. The aim of this study was to find whether probiotic E. coli strain Nissle 1917 (EcN) influences the pharmacokinetics of concom...

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Bibliographic Details
Main Authors: Zuzana Matuskova, Eva Anzenbacherova, Rostislav Vecera, Helena Tlaskalova-Hogenova, Milan Kolar, Pavel Anzenbacher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3914806?pdf=render