Functional Dissection of pri-miR-290~295 in Dgcr8 Knockout Mouse Embryonic Stem Cells

Functional Dissection of pri-miR-290~295 in Dgcr8 Knockout Mouse Embryonic Stem Cells

The DiGeorge syndrome critical region gene 8 (Dgcr8) knockout strategy has been widely used to study the function of canonical microRNAs (miRNAs) in vitro and in vivo. However, primary miRNA (pri-miRNA) transcripts are accumulated in Dgcr8 knockout cells due to interrupted processing. Whether abnorm...

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Bibliographic Details
Main Authors: Ming Shi, Jing Hao, Xi-Wen Wang, Le-Qi Liao, Huiqing Cao, Yangming Wang
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
DiGeorge syndrome critical region gene 8
primary microRNA
miR-290~295 cluster
embryonic stem cells
cell cycle
pluripotency
self-renewal
differentiation
Nlrp12
Online Access:https://www.mdpi.com/1422-0067/20/18/4345

Internet

https://www.mdpi.com/1422-0067/20/18/4345

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