Brain-targeted delivery of PEGylated nano-bacitracin A against Penicillin-sensitive and -resistant Pneumococcal meningitis: formulated with RVG29 and Pluronic® P85 unimers

Brain-targeted delivery of PEGylated nano-bacitracin A against Penicillin-sensitive and -resistant Pneumococcal meningitis: formulated with RVG29 and Pluronic® P85 unimers

Pneumococcal meningitis (PM), caused by Streptococcus pneumonia, remains a high-burden disease in developing countries. Antibiotic therapy has been limited due to the inefficiency of drug transport across the blood-brain barrier (BBB) and the emergence of drug-resistant strains. In our preliminary s...

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Bibliographic Details
Main Authors: Wei Hong, Zehui Zhang, Lipeng Liu, Yining Zhao, Dexian Zhang, Mingchun Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
pneumococcal meningitis
blood-brain barrier
rabies virus glycoprotein
pluronic® p85 unimers
rvg29-nano-bap85
Online Access:http://dx.doi.org/10.1080/10717544.2018.1486473

Internet

http://dx.doi.org/10.1080/10717544.2018.1486473

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