Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis

B cells produce antibodies to mediate various immune functions, but are also reported to negatively regulate immune responses. Here, the authors show that a subset of mature B cells expressing low levels of IgD, present in both mice and human, may pursue this regulatory function indirectly by induci...

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Bibliographic Details
Main Authors: Avijit Ray, Mohamed I. Khalil, Kirthi L. Pulakanti, Robert T. Burns, Cody J. Gurski, Sreemanti Basu, Demin Wang, Sridhar Rao, Bonnie N. Dittel
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08122-9