Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast.

Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast.

The Saccharomyces cerevisiae High-Osmolarity Glycerol (HOG) pathway is a conserved mitogen-activated protein kinase (MAPK) signal transduction system that often serves as a model to analyze systems level properties of MAPK signaling. Hog1, the MAPK of the HOG-pathway, can be activated by various env...

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Bibliographic Details
Main Authors: Peter Dinér, Jenny Veide Vilg, Jimmy Kjellén, Iwona Migdal, Terese Andersson, Marinella Gebbia, Guri Giaever, Corey Nislow, Stefan Hohmann, Robert Wysocki, Markus J Tamás, Morten Grøtli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3104989?pdf=render

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http://europepmc.org/articles/PMC3104989?pdf=render

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