PKCε signalling activates ERK1/2, and regulates aggrecan, ADAMTS5, and miR377 gene expression in human nucleus pulposus cells.

PKCε signalling activates ERK1/2, and regulates aggrecan, ADAMTS5, and miR377 gene expression in human nucleus pulposus cells.

The protein kinase C (PKC) signaling, a major regulator of chondrocytic differentiation, has been also implicated in pathological extracellular matrix remodeling, and here we investigate the mechanism of PKCε-dependent regulation of the chondrocytic phenotype in human nucleus pulposus (NP) cells der...

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Bibliographic Details
Main Authors: Emmanouella Tsirimonaki, Constantinos Fedonidis, Spiros G Pneumaticos, Adamantios A Tragas, Ioannis Michalopoulos, Dimitra Mangoura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3842981?pdf=render

Internet

http://europepmc.org/articles/PMC3842981?pdf=render

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