Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response

Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response

The TTT complex is composed of the three essential proteins Tel2, Tti1, and Tti2. The complex is required to maintain steady state levels of phosphatidylinositol 3-kinase-related kinase (PIKK) proteins, including mTOR, ATM/Tel1, ATR/Mec1, and TRRAP/Tra1, all of which serve as regulators of critical...

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Bibliographic Details
Main Authors: Kyle S. Hoffman, Martin L. Duennwald, Jim Karagiannis, Julie Genereaux, Alexander S. McCarton, Christopher J. Brandl
Format: Article
Language:English
Published: Oxford University Press 2016-06-01
Series:G3: Genes, Genomes, Genetics
Subjects:
TTT complex
PIKK proteins
heat shock response
chaperone
protein expression
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.116.029520

Internet

http://g3journal.org/lookup/doi/10.1534/g3.116.029520

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