Proteomic Characterization of Synaptosomes from Human Substantia Nigra Indicates Altered Mitochondrial Translation in Parkinson’s Disease

Proteomic Characterization of Synaptosomes from Human Substantia Nigra Indicates Altered Mitochondrial Translation in Parkinson’s Disease

The pathological hallmark of Parkinson’s disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular...

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Bibliographic Details
Main Authors: Sarah Plum, Britta Eggers, Stefan Helling, Markus Stepath, Carsten Theiss, Renata E. P. Leite, Mariana Molina, Lea T. Grinberg, Peter Riederer, Manfred Gerlach, Caroline May, Katrin Marcus
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
synaptosomes
proteomics
Parkinson’s disease
substantia nigra pars compacta
mitochondrial pathology
mitochondrial translation
Online Access:https://www.mdpi.com/2073-4409/9/12/2580

Internet

https://www.mdpi.com/2073-4409/9/12/2580

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