A chromosomal memory triggered by Xist regulates histone methylation in X inactivation.
We have elucidated the kinetics of histone methylation during X inactivation using an inducible Xist expression system in mouse embryonic stem (ES) cells. Previous reports showed that the ability of Xist to trigger silencing is restricted to an early window in ES cell differentiation. Here we show t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2004-07-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC449785?pdf=render |