Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection

Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection

Abstract Background The CRISPR/Cas9 system has been widely used for genome editing in mammalian cells. CXCR4 is a co-receptor for human immunodeficiency virus type 1 (HIV-1) entry, and loss of CXCR4 function can protect cells from CXCR4 (X4)-tropic HIV-1 infection, making CXCR4 an important target f...

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Bibliographic Details
Main Authors: Qiankun Wang, Shuliang Chen, Qiaoqiao Xiao, Zhepeng Liu, Shuai Liu, Panpan Hou, Li Zhou, Wei Hou, Wenzhe Ho, Chunmei Li, Li Wu, Deyin Guo
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Retrovirology
Subjects:
CXCR4
HIV-1
Primary CD4+ T cells
Adeno-associated virus
CRISPR/SaCas9
Online Access:http://link.springer.com/article/10.1186/s12977-017-0375-0

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http://link.springer.com/article/10.1186/s12977-017-0375-0

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