Brain cyclooxygenase-2 mediates interleukin-1-induced cellular activation in preoptic and arcuate hypothalamus, but not sickness symptoms

Brain cyclooxygenase-2 mediates interleukin-1-induced cellular activation in preoptic and arcuate hypothalamus, but not sickness symptoms

Interleukin-1ß acts on the CNS to induce fever, neuroendocrine activation, and behavioral changes, but cannot passively cross the blood–brain barrier. According to a widely accepted hypothesis interleukin-1ß induces the synthesis of cyclooxygenase-2 at the blood–brain interface, which produces prost...

Full description

Bibliographic Details
Main Authors: Agnès Nadjar, Julie Sauvant, Chantal Combe, Patricia Parnet, Jan Pieter Konsman
Format: Article
Language:English
Published: Elsevier 2010-09-01
Series:Neurobiology of Disease
Subjects:
Anorexia
Arcuate hypothalamus
c-Fos
corticosterone
Cyclooxygenase-2
Extracellular signal-regulated kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110001567

Internet

http://www.sciencedirect.com/science/article/pii/S0969996110001567

Similar Items