Chronic Intermittent Hypoxia Reduces the Effects of Glucosteroid in Asthma via Activating the p38 MAPK Signaling Pathway

Chronic Intermittent Hypoxia Reduces the Effects of Glucosteroid in Asthma via Activating the p38 MAPK Signaling Pathway

AimsObstructive sleep apnea (OSA) is a risk factor for steroid-resistant (SR) asthma. However, the underlying mechanism is not well defined. This study aimed to investigate how chronic intermittent hypoxia (CIH), the main pathophysiology of OSA, influenced the effects of glucocorticoids (GCs) on ast...

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Bibliographic Details
Main Authors: Li Liang, Xin Gu, Hai Ji Shen, Yu Heng Shi, Yao Li, Jie Zhang, Yan Yan Chen, Zhen He Chen, Jia Yun Ma, Qing Yun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
p38 MAPK pathway
ovalbumin
chronic intermittent hypoxia
asthma
glucosteroid
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.703281/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.703281/full

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