Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 68Ga-NOTA-anti-MMR nanobody: non-invasive imaging of atherosclerotic plaques

Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 68Ga-NOTA-anti-MMR nanobody: non-invasive imaging of atherosclerotic plaques

Abstract Background Rupture-prone atherosclerotic plaques are characterized by heavy macrophage infiltration, and the presence of certain macrophage subsets might be a sign for plaque vulnerability. The mannose receptor (MR, CD206) is over-expressed in several types of alternatively activated macrop...

Full description

Bibliographic Details
Main Authors: Zohreh Varasteh, Sarajo Mohanta, Yuanfang Li, Nicolás López Armbruster, Miriam Braeuer, Stephan G. Nekolla, Andreas Habenicht, Hendrik B. Sager, Geert Raes, Wolfgang Weber, Sophie Hernot, Markus Schwaiger
Format: Article
Language:English
Published: SpringerOpen 2019-01-01
Series:EJNMMI Research
Subjects:
Atherosclerotic plaques
Non-invasive imaging
Inflammation
Alternatively differentiated macrophages
Mannose receptor
PET/CT
Online Access:http://link.springer.com/article/10.1186/s13550-019-0474-0

Internet

http://link.springer.com/article/10.1186/s13550-019-0474-0

Similar Items