Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice.

Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice.

BACKGROUND:Radiation-induced gastrointestinal syndrome (RIGS) results from a combination of direct cytocidal effects on intestinal crypt and endothelial cells and subsequent loss of the mucosal barrier, resulting in electrolyte imbalance, diarrhea, weight loss, infection and mortality. Because R-spo...

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Bibliographic Details
Main Authors: Payel Bhanja, Subhrajit Saha, Rafi Kabarriti, Laibin Liu, Namita Roy-Chowdhury, Jayanta Roy-Chowdhury, Rani S Sellers, Alan A Alfieri, Chandan Guha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2777375?pdf=render

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http://europepmc.org/articles/PMC2777375?pdf=render

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