Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4+

The minichromosome maintenance (MCM) complex is the conserved helicase motor of the eukaryotic replication fork. Mutations in the Mcm4 subunit are associated with replication stress and double strand breaks in multiple systems. In this work, we characterize a new temperature-sensitive allele of Schi...

Full description

Bibliographic Details
Main Authors: Nimna S. Ranatunga, Susan L. Forsburg
Format: Article
Language:English
Published: Oxford University Press 2016-10-01
Series:G3: Genes, Genomes, Genetics
Subjects:
MMS
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.116.033571