Low expression of SPARC in gastric cancer-associated fibroblasts leads to stemness transformation and 5-fluorouracil resistance in gastric cancer

Low expression of SPARC in gastric cancer-associated fibroblasts leads to stemness transformation and 5-fluorouracil resistance in gastric cancer

Abstract Background The aim of the present study was to clarify the correlations between SPARC expression in gastric cancer-associated fibroblasts (GCAFs) and the prognosis of patients with gastric cancer and to elucidate the role of GCAF-derived SPARC in stemness transformation and 5-fluorouracil r...

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Bibliographic Details
Main Authors: Yongchen Ma, Jing Zhu, Shanwen Chen, Ju Ma, Xiaoqian Zhang, Sixia Huang, Jianwen Hu, Taohua Yue, Junling Zhang, Pengyuan Wang, Xin Wang, Long Rong, Hongjie Guo, Guowei Chen, Yucun Liu
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cancer Cell International
Subjects:
SPARC
Cancer-associated fibroblasts
Gastric cancer
Stemness
Drug resistance
Online Access:http://link.springer.com/article/10.1186/s12935-019-0844-8

Internet

http://link.springer.com/article/10.1186/s12935-019-0844-8

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