n-6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer

n-6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer

The farnesoid-X-receptor (FXR) protects against inflammation and cancer of the colon through maintenance of intestinal bile acid (BA) homeostasis. Conversely, higher levels of BA and cyclooxygenase-2 (COX-2) are risk factors for inflammation and cancer of the colon. In the United States, n-6 linolei...

Full description

Bibliographic Details
Main Authors: Donato F. Romagnolo, Micah G. Donovan, Tom C. Doetschman, Ornella I. Selmin
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Nutrients
Subjects:
n-6 linoleic acid
high-fat diet (HFD)
bile acids
epigenetics
farnesoid-X-receptor (FXR)
cyclooxygenase-2 (COX-2)
Apc
colon cancer
Online Access:http://www.mdpi.com/2072-6643/11/1/171

Internet

http://www.mdpi.com/2072-6643/11/1/171

Similar Items