E3 Ligase ITCH Interacts with the Z Matrix Protein of Lassa and Mopeia Viruses and Is Required for the Release of Infectious Particles

E3 Ligase ITCH Interacts with the Z Matrix Protein of Lassa and Mopeia Viruses and Is Required for the Release of Infectious Particles

Lassa virus (LASV) and Mopeia virus (MOPV) are two closely related, rodent-born mammarenaviruses. LASV is the causative agent of Lassa fever, a deadly hemorrhagic fever endemic in West Africa, whereas MOPV is non-pathogenic in humans. The Z matrix protein of arenaviruses is essential to virus assemb...

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Bibliographic Details
Main Authors: Nicolas Baillet, Sophie Krieger, Xavier Carnec, Mathieu Mateo, Alexandra Journeaux, Othmann Merabet, Valérie Caro, Frédéric Tangy, Pierre-Olivier Vidalain, Sylvain Baize
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Viruses
Subjects:
lassa fever
lasv
mopv
itch
z matrix protein
yeast two-hybrid screening
egress
infection
Online Access:https://www.mdpi.com/1999-4915/12/1/49

Internet

https://www.mdpi.com/1999-4915/12/1/49

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